Spastic paraplegia 4 (SPG4; generally known as SPAST-HSP) is characterized by insidiously progressive bilateral decreased-limb gait spasticity. More than 50% of affected people have some weakness in the legs and impaired vibration sense at the ankles.???? ??? ? ?? ??: ??? ??? ???? ???? ??? ? ????.??? ?? ??: ???? ??? ??? ? ?? ?? ??? ?? ???? ?????.??